Abstract

Alcohol is produced in different forms and its consumption has been abused, leading to various social and health challenges. This work investigated the ameliorative effect of red wine on ethanol-induced toxicity of some biomolecules in wistar albino rats. Equal concentrations (6%) of ethanol and red wine were administered to two separate groups of rats. Distilled water was served to the control rats. After 8 wks, an immune response was elicited by an intraperitoneal injection of lipopolysaccharide (LPS). The concentrations of both biochemical (glucose, total protein, albumin, AST, and ALT) and haematological parameters (immune cells) were found to be significantly lower (P < 0.05) in ethanol-consuming rats compared to the controls. In the red wine-consuming rats, there were no statistically significant (P > 0.05) differences in the concentrations of the parameters compared to the control group. There were significant (P < 0.05) negative changes observed in relation to haematological parameters when LSP was administered to the ethanol-consuming rats, but these were unchanged in LPS-fed rats that consumed the same amount of ethanol in form of red wine. Although, a recent study observed that no consumption limit can be said to be safe for alcohol consumption, the present study revealed that red wine has clear non-toxic benefits on biochemical and haematological parameters in wistar rats.